Abstract
ObjectiveTo investigate the clinical characteristics, epidemiological characteristics, and transmissibility of coronavirus disease 2019 (COVID-19) in a family cluster outbreak transmitted by a 3-month-old confirmed positive infant.MethodsField-based epidemiological methods were used to investigate cases and their close contacts. Real-time fluorescent reverse transcription polymerase chain reaction (RT-PCR) was used to detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) for all collected specimens. Serum SARS-CoV-2 IgM and IgG antibodies were detected by Chemiluminescence and Gold immnnochromatography (GICA).ResultsThe outbreak was a family cluster with an attack rate of 80% (4/5). The first case in this family was a 3-month-old infant. The transmission chain was confirmed from infant to adults (her father, mother and grandmother). Fecal tests for SARS-CoV-2 RNA remained positive for 37 days after the infant was discharged. The infant’s grandmother was confirmed to be positive 2 days after the infant was discharged from hospital. Patients A (3-month-old female), B (patient A’s father), C (patient A’s grandmother), and D (patient A’s mother) had positive serum IgG and negative IgM, but patients A’s grandfather serum IgG and IgM were negative.ConclusionSARS-CoV-2 has strong transmissibility within family settings and presence of viral RNA in stool raises concern for possible fecal–oral transmission. Hospital follow-up and close contact tracing are necessary for those diagnosed with COVID-19.
Highlights
In December 2019, coronavirus disease 2019 (COVID19) was initially reported in Wuhan, Hubei Province, central China
A Chinese study collected 377 COVID19 clusters (1719 cases) from January 1, 2020 to February 20, 2020, of which 297 family clusters (79%); 39 clusters of dining(10%); 23 clusters (6%) in large shopping centers or supermarkets; 12 work unit groups (3%) [6]. These results suggest outbreak clusters of COVID-19 mainly occur in families
Overview of the family cluster outbreak At noon on January 21, 2020, a family of four, patients A (3-month-old female), B, C, and D, departed from Wuhan City, Hubei Province, and arrived at Xiaogan City, Hubei Province to pick up E, patient A’s grandfather
Summary
In December 2019, coronavirus disease 2019 (COVID19) was initially reported in Wuhan, Hubei Province, central China. A Chinese study collected 377 COVID19 clusters (1719 cases) from January 1, 2020 to February 20, 2020, of which 297 family clusters (79%); 39 clusters of dining(10%); 23 clusters (6%) in large shopping centers or supermarkets; 12 work unit groups (3%) [6]. These results suggest outbreak clusters of COVID-19 mainly occur in families. All previously reported family outbreak clusters in China characterize transmission from adults to children [4, 8, 9]. This report includes clinical and epidemiological characteristics surrounding a family outbreak cluster initiated by a 3-month-old infant
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