EPIDEMIOLOGIC PROFILE OF SYNDROMIC AND NONSYNDROMIC ODONTOGENIC KERATOCYST CASES: A 12-YEAR RETROSPECTIVE STUDY

Abstract

Objective A retrospective study of the incidence of odontogenic keratocysts (OKCs) and the association with nevoid basal cell carcinoma syndrome (NBCCS) diagnosed in an oral pathology laboratory (2006 to 02/2018). Study Design The data collected were age, sex, ethnic group, association with NBCCS, location, radiographic aspects, and number of lesions. Results From 381 biopsy reports of odontogenic cysts selected in the period, 54 (14%) were diagnosed as OKC. Cases associated with NBCCS were 18, of which 50% were multiple and multilocular lesions, 66.7% of patients were male, and the mean age was 21.5 years. From the 36 nonsyndromic biopsy reports, 66.7% were unilocular lesions, 52.8% of patients were male, and the mean age was 41.8 years. White patients represented 93.75% of all data. The most frequent location was the mandible, and the occurrence of maxillary lesions was more frequent in syndromic patients. Conclusion The occurrence of OKC in syndromic patients occurs at an earlier age, with a higher prevalence of multiple lesions and a multilocular aspect as well as a greater incidence of cases occurring in the maxilla compared with nonsyndromic cases. A retrospective study of the incidence of odontogenic keratocysts (OKCs) and the association with nevoid basal cell carcinoma syndrome (NBCCS) diagnosed in an oral pathology laboratory (2006 to 02/2018). The data collected were age, sex, ethnic group, association with NBCCS, location, radiographic aspects, and number of lesions. From 381 biopsy reports of odontogenic cysts selected in the period, 54 (14%) were diagnosed as OKC. Cases associated with NBCCS were 18, of which 50% were multiple and multilocular lesions, 66.7% of patients were male, and the mean age was 21.5 years. From the 36 nonsyndromic biopsy reports, 66.7% were unilocular lesions, 52.8% of patients were male, and the mean age was 41.8 years. White patients represented 93.75% of all data. The most frequent location was the mandible, and the occurrence of maxillary lesions was more frequent in syndromic patients. The occurrence of OKC in syndromic patients occurs at an earlier age, with a higher prevalence of multiple lesions and a multilocular aspect as well as a greater incidence of cases occurring in the maxilla compared with nonsyndromic cases.