Abstract
Uveal melanoma is the most common primary intraocular malignancy in adults. The development of distant metastases is associated with a poor prognosis. Ephrine receptors (Eph) are the largest subpopulation of tyrosine kinase receptors. They play an important role in processes related to the formation and progression of cancer. The aim of the study was to evaluate the expression of ephrin receptors EphA1, EphA5, and EphA7 in uveal melanoma and its associations with clinicopathological parameters, overall survival, and disease-free survival. The study included 94 previously untreated patients who underwent enucleation due to uveal melanoma. High expression of EphA1 was positively correlated with a smaller tumor size, less frequent extra-scleral extension, lower mitotic activity, and more frequent vitreous hemorrhage. High expression of EphA5 was associated with less frequent chromosome 3 loss, absence of distant metastases, and more frequent vitreous hemorrhage. High expression of EphA7 was associated with a more frequent primary tumor location in the posterior pole. High EphA5 expression was associated with longer overall survival time. The above findings indicate that high expression of EphA1 and EphA5 can be considered a beneficial prognostic factor in uveal melanoma.
Highlights
Uveal melanoma is the most common primary intraocular malignancy in adults, with a mean age-adjusted incidence of 5.1 cases per million per year [1]. 5-year survival rates depend on the stage of disease [2,3]
It is worth emphasizing that the research results are divergent for each of the receptors analyzed. Both increased and decreased expression may be associated with a worse prognosis. This is because the effect of Ephrine receptors (Eph)/ephrin signaling on cellular processes is complex and highly dependent on the cellular context and stage of the disease [11]
In clear-cell renal cell carcinoma, high expression of EphA1 is significantly associated with young age, sex, and higher histopathological grade [21]
Summary
Uveal melanoma is the most common primary intraocular malignancy in adults, with a mean age-adjusted incidence of 5.1 cases per million per year [1]. 5-year survival rates depend on the stage of disease [2,3]. Uveal melanoma is the most common primary intraocular malignancy in adults, with a mean age-adjusted incidence of 5.1 cases per million per year [1]. 5-year survival rates depend on the stage of disease [2,3]. Uveal melanoma has a high tendency to metastasize, which is associated with dramatically poor prognosis. 50% of patients develop metastasis, irrespective of the type of treatment used in primary disease [4]. 8% of patients with metastatic melanoma survive years [2]. Life 2020, 10, 225 method used [5]. This demonstrates the need to search for new prognostic factors and new potential treatment options
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
