Abstract
PIK3CA-related overgrowth spectrum (PROS) and large PIK3CA-associated lymphatic malformations of the head and neck (HNLM) pose unique treatment challenges. Traditional therapies often include multiple invasive (ie, sclerotherapy or surgery) interventions with suboptimal functional and cosmetic outcomes. HNLM is the most common pathology in the head and neck with PROS, and additional pathology may include facial infiltrating lipomatosis (FIL), megalencephaly capillary malformation syndrome (MCAP), Klippel-Trenaunay-Weber syndrome and congenital lipomatous overgrowth, vascular malformations, epidermal nevi, scoliosis and spinal syndrome (CLOVES).
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