Abstract
Wang et al (J Clin Invest 2021;131:e138637, PMID 34596051) developed a genetic system for ablating cardiomyocytes (CMs) that reside within the atrioventricular conduction system (AVCS). Adult mouse AVCS ablation resulted in regenerative failure characterized by persistent atrioventricular conduction defects and contractile dysfunction. In contrast, AVCS in neonatal mice exhibited evidence of plasticity with recovery from injury in a subset of mice. CM proliferation did not completely account for the observed functional recovery, suggesting that mechanisms regulating recovery are distinct from cardiac regeneration associated with ventricular injury.
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