Abstract
The determination of 29 enzyme activities in human liver tissue taken immediately after death from liver failure showed a loss of specific functions in favor of pathways which predominate in fetal or neoplastic cells. The determination of cellular and plasma-specific enzymes in serum before and during hepatic failure showed that the impaired synthesis capacity of the liver is reflected in the patterns of both groups of enzymes in serum. In acute viral hepatitis, the prognostic value of plasma-specific enzymes is better than that of cellular enzymes in serum, while in coma, success of hemo-perfusion could be better predicted by determination of the latter. Immediately after liver transplantation, liver-specific cell enzymes, and later, plasma-specific enzymes in serum, can be used to estimate the condition of the liver and the patient’s chance of survival. The ratio CHE/GPT in serum is proposed as a prognostic index.
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