Abstract
The TPNH dependent monooxygenases, which are localized in the endoplasmic reticulum of the liver cell, have been implicated in the majority of drug oxidations. In addition to these enzymes, however, there are a number of other classes of enzymes which are involved in the oxidation and reduction of foreign chemicals in the body. These include among others the oxido-reductases as well as those enzymes responsible for the oxidation of aldehydes to carboxylic acids. The oxidoreductases are a class of dehydrogenases that catalyze the conversion of alcohols to aldehydes or ketones or alternatively the reduction of carbonyl compounds to alcohols.
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