Abstract
The cause of the oncological diseases in children and the specific spectrum of this pathology, with hemangiomas prevailing among benign tumors (BT), and leukemia, lymphomas, and neural tissue tumors among malignant neoplasms (MN), remains unknown. The authors studied the similarities and differences of the connections between environmental factors, benign tumors and MN, as well as the relations between BT and MN. The causality of the so-called “sporadic” fluctuations in the incidence of neoplasms and their relations with environmental factors were revealed. A hypothesis of environmentally-induced alternative oncogenesis is suggested. According to the hypothesis, fetal hemoglobin enhances environmentally-related oxidative stress (EROS), leading to epigenomic regulation disorder of SEMA 7A and MICAL family proteins in the endothelium, axon growth cone, and hematopoietic stem cells.
Highlights
The role of environmental factors in oncogenesis does not cause any doubts [1]
The preconceptive effect of solar activity is important for hemangiomas, and postnatal for leukemia
The smoke of forest fires affects the incidence of leukemia being exposed to ontogenesis during the preconceptive period, while for the incidence of hemangiomas, a connection with its postnatal exposure has been revealed [2,4]
Summary
The role of environmental factors in oncogenesis does not cause any doubts [1]. The mechanism of development of many forms of tumors is still unclear. Until now, the cause of the oncological diseases in children and the special spectrum of this pathology with the predominance of hemangiomas among benign tumors (BT), and leukemia, lymphomas, and nervous tissue tumors among malignant neoplasms (MN), remains unknown. While in adults the majority of cancer forms are caused by a prolonged exposure to specific organs and systems with a fairly well-known etiopathogenesis, oncological pathology occurs in children, as a rule, in the absence of signs of obvious oncogenic causes. Detecting the causes and ways of developing neoplasms in children is a very urgent objective aimed at working out measures for their prevention
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