Abstract
Molecular and cellular aspects of pro-oxidant environmental xenobiotics: free radical reactions in human disease radicals and inflammation - mediators and modulators autoimmunology caused by oxidising foreign compounds role of oxidative stress in chemical carcinogenesis proposed mechanisms of arsenic toxicity carcinogenesis redox regulation of gene expression and transcription factors in response to environmental oxidants. Target organs of environmental oxidants - lung: cigarette smoking and pulmonary oxidative damage the health effects of diesel exhaust and diesel exhaust particles the role of free radicals in asbestos- and silica-induced fibrotic lung diseases reactive oxygen and silica-induced carcinogenesis atmospheric oxidants and respiratory tract surfaces. Target organs of environmental oxidants - skin: redox modulation and oxidative stress in dermatotoxicology dermatotoxicology of environmental and occupational hazards - agents and action photo-oxidative stress in skin and regulation of gene expression ozone induces stress in the skin barrier immunotoxicology of oxidizing chemicals in the skin. Target organs of environmental oxidants - eye: environmental stressors and the eye - an overview free radicals and ageing of anterior segment tissues of the eye the role of ocular free radicals in age-related macular degeneration nutritional influences on risk for cataract.
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