Abstract
Electron microscopists studying viruses during the last decade have concentrated heavily upon morphogenesis and viral ultrastructure. These efforts have borne rich harvests of important information about the macromolecular configuration of viruses and have strongly influenced the design of our present viral classification schemes. Viruses such as the Epstein-Barr herpes particle and several members of the “C”-particle class of viruses were recognized by electron microscopy before they could be effectively detected or quantitated biologically. Once such viruses are discovered, however, it is useful to know how many particles are present in certain materials. Thus, quantitation of virus particles (particle counting) has attracted the attention of those interested in viruses for which there is still no adequate biological detection or quantitation system.
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