Abstract
To describe the entry of Dengue virus (DENV) serotypes in Brazil and its federative units. A systematic review of studies published between 1980 and 2018 in databases and in the gray literature was performed using descriptors related to the years of entry of the DENV serotypes. Additionally, experts and official sources of information (Brazilian Ministry of Health) were consulted. From 100 publications selected for the systematic review, 26 addressed the entry of DENV serotypes in the North region of the country, 33 in the Northeast, 24 in the Southeast, 14 in the Central-West, and five in the South. DENV-1 and DENV-4 were introduced in the North region in 1981. DENV-2 was introduced in the Southeast in 1990. DENV-3 was introduced in the North in 1999. The rapid expansion of dengue throughout the Brazilian territory was verified from the second half of the 1980s, with the gradual entry of the four serotypes, which resulted in the emergence of epidemics of arbovirus, which are currently verified in the country. Considering the epidemiology of the disease, more information should be disseminated and published in the wide-ranging scientific literature for a better understanding of the spread and circulation of DENV serotypes.
Highlights
Dengue represents an important vector-borne disease worldwide due to its morbidity and impacts on public health[1]
The present study aims to present a systematic review of the scientific literature on the entry of Dengue virus (DENV) serotypes in Brazil and its federative units over the years
This is a systematic review of the literature from different electronic databases, using descriptors associated with the year of entry of DENV serotypes and its circulation in Brazil and its 27 federative units
Summary
Dengue represents an important vector-borne disease worldwide due to its morbidity and impacts on public health[1]. In Brazil, the disease is currently the object of largest public health programs, which focus on Aedes aegypti control. This mosquito is adapted to reproduce in domestic and peridomestic environments, using different types of stagnant water containers[2]. The first dengue epidemic clinically and laboratory-confirmed in the country occurred in 1981 and 1982, in Boa Vista (state of Roraima) and was caused by serotypes DENV-1 and DENV-413. In 1999, DENV-3 was introduced in the states of Amapá, Pará, Roraima, and Tocantins (data provided by the Brazilian Ministry of Health). The present study aims to present a systematic review of the scientific literature on the entry of DENV serotypes in Brazil and its federative units over the years
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