Abstract
The intestinal absorption of 64CuCl2, 52MnCl2 and 203HgCl2 was compared with those of biliary excreted radiometals in rats during 24 h after intraduodenal administration. Biliary excreted metals were obtained from rats (donors) given previously intravenously 64CuCl2, 52MnCl2 and 203HgCl2. The metals in form of chloride salts as well as the metals excreted via bile were given to control or acceptor rats in the same dose intraduodenally. In manganese, given as 52MnCl2 15.04±8.48%, whereas given biliary excreted 52Mn 35.45±5.72% was absorbed. Biliary excreted manganese is probably in the bile in form suitable for intestinal absorption. In both other metals the intestinal absorption was higher when metal in form of chloride salt was administered (in 64Cu 46.45±11.46% respectively 16.74±8.53%; in 203Hg 40.9±8.52% respectively 21.08±10.7%).
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