Abstract
ABSTRACT The objective of this study is to obtain precise medication delivery by combining the drug xovoltib with chitosan nanoparticles that are synthesized from the cuttlebone of sepia. The effectiveness of this drug delivery system will be evaluated by examining its ability to inhibit the growth of cancer cells using the MCF-7 cell line. This study synthesized chitosan from the cuttlebone of sepia and complexed it with Tri Polyphosphate to form Chitosan-Tri Poly phosphate-nanoparticles (CS-TPP-NPS) using the ionotropic gelation method. The UV-visible absorption study showed a strong characteristic band ranging between 200–800 nm. The 2θ value at 20.0 degrees and 20.63 degrees indicates the crystalline nature of CS-TPP-NPS loaded with xovoltib. HR-SEM image but the morphology of chitosan nanoparticles was magnified with a high voltage of 20,000 KV and observed as spherical, porous and smooth. The in vitro drug delivery of xovoltib-loaded CS-TPP was tested against MCF-7 which had lowered the cell viability rate at 300 µl/mL.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
