Abstract
Vibrio vulnificus protease, which had been purified from the culture supernatant of a strain isolated from a septicemic human patient, enhanced hypodermic vascular permeability and formed hemorrhagic spot caused by tissue destruction in a dose-dependent manner within a range of 0.3–10.0 μg when injected intradermally (i.d.) into rat dorsal skin. Enhancement of permeability was observed within 2 min, and the permeability-enhancing reaction terminated at 10 min after the injection. This reaction was blocked by simultaneous injection of an antihistamine, diphenhydramine, suggesting that the permeability-enhancing reaction of V. vulnificus protease was due to histamine release in vivo. Hemorrhage caused by V. vulnificus protease was also rapidly observed, but this reaction was not inhibited by the antihistamine.
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