Abstract
Triacetoneamine-N-oxyl (2,2,6,6-tetramethyl-4-piperidone-1-oxyl), a highly water-soluble, stable free radical, has been shown to preferentially sensitize anoxic E. coli B/r to the lethal effects of X-rays. In the absence of excess radical scavengers in the medium the maximum sensitization is reached at 10-3 M, at which concentration the triacetone-amine-N-oxyl (TAN) is about 60 to 70% as effective as oxygen. This concentration is lower, by a factor of 10, than that at which previously studied analogous compounds such as di-t-butyl nitroxide (DTBN) were equally effective. TAN does not sensitize aerobic bacteria, with the result that it reduces the oxygen effect. The normal sensitization due to oxygen in E. coli B/r is decreased from a dose-reduction factor of about 4.0 to about 1.5, by the presence of 10-3 M TAN. The compound is well tolerated intraperitoneally in mice, which should permit the performance of in vivo sensitization experiments.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
