Abstract
The antifungal activity of curcumin against seven Candida species was studied by investigating the growth of 200 clinical isolates from patients with fungal infections. The MICs of curcumin against Candida species were in the range of 32 to 128 μg/mL. The interaction of curcumin with amphotericin B or fluconazole against these fungi was determined by FIC index and % reduction in turbidity. Synergistic effect was shown in all combinations of curcumin and amphotericin B; whereas both synergistic and additive effects were observed in the combinations of curcumin and fluconazole. This evidence suggests that when curcumin is combined with amphotericin B or fluconazole, it could provide greater fungicidal effects for the treatment of systemic fungal infections such as candidiasis and candidemia.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.