Abstract
This paper presents evidence of a significantly enhanced humoral immune response to sheep red cells following thermal injury, as assayed by direct hemolytic antibody plaque formation. An increase in the number of 19 S IgM antibody-secreting cells from the spleen was observed in rats up to 16 days after a 30-percent total body surface area, third-degree, scald burn. Since this enhancement was present in animals immunized up to 20 days postburn, the possible role of adjuvants liberated by the burn injury is considered. The role of the interaction between thymus-processed and marrow-derived lymphocytes in this enchancement is also discussed.
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