Abstract
A supersaturating self-emulsifying drug delivery system (S-SEDDS) was prepared and evaluated for enhanced dissolution of celecoxib (CXB), a poorly water-soluble drug. The selected CXB-dissolved SEDDS formulation consisting 10% Capryol 90 (oil), 45% Tween 20 (surfactant), and 45% Tetraglycol (cosurfactant) had the characteristics of small droplet size and great solubility as 208nm and 556.7mg/mL in average, respectively. CXB dissolution from SEDDS in simulated gastric fluid was increased to about 20% for the initial period of 5min, but decreased to a half level as time elapsed. Thus, precipitation inhibitors were screened to stabilize the supersaturation. The stabilizing effect of Soluplus, an amphiphilic copolymer, was concentration-dependent, revealing the greatest dissolution of approximately 90% level with delayed drug crystallization by the addition of the copolymer. CXB dissolution from S-SEDDS was pH-independent. We concluded that S-SEDDS formulation would be very useful in the future for developing oral delivery product of poorly water-soluble drugs.
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