Enhanced Computer-Aided Digital Imaging Technique for Predictions in Breast Cancer

Abstract

Background: Breast cancer (BRCA) is the most frequently diagnosed cancer in women, with a rise in occurrences and fatalities. The field of BRCA prediction and diagnosis has witnessed significant advancements in recent years, particularly emphasizing enhanced computer-aided digital imaging techniques, and has emerged as a powerful ally in the prediction of BRCA through histopathology image analysis. A number of approaches have been suggested in recent years for the categorization of histopathology BRCA images into benign and malignant as it examines the images at cellular level. The histopathology slides must be manually analysed which is time consuming and tiresome and is prone to human error. Additionally, different laboratories occasionally have different interpretation of these images. Methods: This paper focuses on implementing a framework for Computer-Aided digital imaging technique that can serve as a decision support. With recent advancements in computing power the analysis of BRCA histopathology image samples has become easier. Stain normalization (SN), segmentation, feature extraction and classification are the steps to categorize the cancer into benign and malignant. Nuclei segmentation is a crucial step that needs to be taken into account in order to establish malignancy. These are considered essential for early diagnosis of BRCA. A unique method proposed for BRCA prediction is put forward. To maximize the prediction accuracy, the suggested method is integrated with machine learning (ML) techniques and clinical data is used to evaluate the suggested approach. Results: This strategy is adaptable to many cancer types and imaging techniques. The suggested technique is applied to clinical data and is integrated with logistic regression and K-Nearest Neighbor resulting in accuracy of 92.10% and 86.89% respectively for BRCA histopathology images. Conclusion: The objective of this work is to validate the proposed model which takes input as feature pattern for a given label. For the collected clinical samples, the model is able to classify the input as benign or malignant. The proposed model worked efficiently for different BC datasets and performed classification task successfully. Integrating mathematical model (MM) with ML model for interpreting histopathology BRCA is a potential area of research in the field of digital pathology.