Abstract
Previous research has demonstrated the anti-tumor properties of Abnormal Savda Munziq (ASMq), a traditional Uyghur compound herbal medicine. The effects of ASMq on cervical carcinomas in U27 tumor-bearing mice is investigated, the effect of adding Fluorouracil (5-FU) is also assessed in this paper. The results demonstrate that ASMq and 5-FU significantly inhibited the proliferation of U27 cells in a time-dependent and dose-dependent manner. Evaluating the interactions between ASMq and 5-FU on U27 cell growth yields a combination index (CI) < 1 in different time periods, suggesting a synergistic effect between the two drugs in vitro. Nuclear magnetic resonance (NMR) analysis demonstrates that ASMq can inhibit enhanced lipid metabolism in tumor mice, enhance the glutamine content, promote lymphocyte and macrophage proliferation, and increase tumor necrosis factor(TNF-α) and interleukin(IL) production, which can enhance the effect of 5-FU on the inhibition of tumors. Also ASMq can reduce the content of ALT and AST in serum. Increased SOD, GSH-Px, and decreased the content of MDA in liver tissue. ASMq has a synergistic effect on liver and tumor pathology, as well as tumor inhibition rate. In addition, ASMq can also enhance the body's antioxidant capacity and improve the body's metabolism, and reduce 5-FU's toxic side effects.
Highlights
Cervical cancer represents one of the most common types of malignant tumor known to gynecological specialists
Normal control group compared with the model group model group compared with the 5-FU group model group compared with the Abnormal Savda Munziq (ASMq).L group model group compared with the ASMq.M group model group compared with the ASMq.H group
Abnormal Savda Munziq is a Uyghur compound medicine comprised of ten separate drugs including Adiantum capillus-veneris L, Alhagi pseudalhagi (Bieb.) Desv, Anchusa italica Retz., Cordia dichotoma G.Forst, Euphorbia humifusa Willd, Foeniculum vulgare Mill, Glycyrrhiza glabra L, Lavandula angustifolia Mill, Melissa officinalis L, and Ziziphus jujuba Mill
Summary
Cervical cancer represents one of the most common types of malignant tumor known to gynecological specialists. Chemical medication therapy remains the most common cancer treatment method in both Chinese and Western medicine, but chemotherapy drugs used to treat tumors inhibit immune function and cause visceral toxic side effects [3,4,5,6]. Uyghur medicine employs mature/clear therapy to correct humoral disorders and treat abnormal savda, and Abnormal Savda Munziq (ASMq) granules are among the most commonly used treatment compound medicine [9,10,11,12]. This study employs metabolomics to observe the effects of ASMq with fluorouracil (5-FU) and attenuated synergies on cervical carcinomas in U27 tumor-bearing mice. We hope that this study will provide an experimental basis for further clinical applications of ASMq
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