Abstract
BACKGROUND In this study we wanted to measure the prevalence of Covid-19 disease among patients of renal transplant. The secondary outcome was to determine the demographic, clinical profile, and functional parameters of renal function and co morbidities associated with outcome in Covid-19 disease and to determine the predictors of mortality in patients who are post kidney transplant. METHODS A longitudinal study of 19 post-transplant patients with Covid-19 infection was conducted in our institute. The inclusion criteria included those patients who were post-transplant with age more than 18 years. The exclusion criteria were patients with graft failure and return to dialysis. The impact of Covid-19 on transplant patients was assessed. Various parameters including age, date of transplant, related or unrelated transplant, change in immunosuppression, comorbidities, graft function, radiological findings of Covid-19, dialysis requirement, and mortality was assessed. The data was analysed using PASW 18 statistical software. Qualitative variables were expressed in frequency and percentage. Quantitative variables as mean and standard deviation. RESULTS Mortality rates of patients with post renal transplant who developed Covid-19 infection was 23 %. The incidence of Covid-19 among transplant population was 3.8 %. In our series most of our patients had live related kidney donor transplantation. And the incidence of co morbidities like hypertension and diabetes was 57 % and 47 % respectively. The factors that was responsible for poor prognosis among transplant patients was graft dysfunction at the time of presentation and the presence of co morbidities. There was worsening of the mean graft functioning after the patient had recovered from Covid, and the mortality of patients on renal replacement therapy and patients on mechanical ventilation was very high. CONCLUSIONS Mortality rates among transplant patients was higher than the general population, and the factors responsible was graft dysfunction and co morbidities. KEY WORDS Covid-19, Post-Transplant, Mortality
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