Abstract
Pongamia pinnata is used in Sri Lankan traditional medicinal systems to cure diseases including microbial infections. Different parts of this plant were investigated for in vitro anti-candidal activity. Extracts of bark, roots and leaves of P. pinnata were examined for their activity on different Candida spp. using well diffusion assay. The extract with best activity was evaluated for its minimum inhibitory concentrations (MIC) using agar dilution method. Its effects on germ tube formation, germ tube elongation and relative cell surface hydrophobicity were determined. The best activity was shown by the root extract of P. pinnata. Neither bark nor leaf showed positive activity. MICs of the root extracts ranged from 1.6 to 12.8 mg/ml. The treatment with root extract of P. pinnata inhibited the germ tube formation, germ tube elongation and relative cell surface hydrophobicity in a dose dependent manner. The results reveal the significant anti-candidal activity of root extracts of P. pinnata. Key words: Anti-candidal, Pongamia pinnata, Candida, germ tube, cell surface hydrophobicity.
Highlights
Plant material has played a major role in traditional medicinal systems throughout the world for centuries.Antimicrobial activity is one such medicinal property of plants in these medicinal systems
Pongamia pinnata is used in Sri Lankan traditional medicinal systems to cure diseases including microbial infections
The results reveal the significant anti-candidal activity of root extracts of P. pinnata
Summary
Antimicrobial activity is one such medicinal property of plants in these medicinal systems This traditional knowledge on antimicrobial activity in higher plants has been systematically proven in numerous studies throughout the world (Chea et al, 2007; More et al., 2008). Fresh bark and leaves of P. pinnata have been used against acute rheumatism, rheumatoid and gonorrheal arthritis, lymphangitis and elephantiasis Seeds of this plant are employed to cure chronic eczema, psoriasis, scabies and ringworm, while the bark is used internally for diarrhea, dyspepsia and flatulence. The plant is popular in Indian traditional medicinal practices It has been used for skin diseases such as eczema, scabies, leprosy, and for ulcers, tumors, piles, enlargement of spleen, vaginal and urinary dis-charges. Seed oil is used in cutaneous affections, herpes and scabies (Khare, 2007)
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