Abstract
Chemical investigation of anti-microbial and anti-fungal components of the leaves of Struchium sparganophora through the application of vacuum liquid chromatogtaphy (VLC), column liquid chromatography (CLC) and preparative thin layer chromatography (PTLC) resulted in isolation of a sesquiterpene lactone, vernodalinol. This compound was subjected to anti-fungal and cytotoxic tests. It exhibited a significant antifungal properties (P>.05) at the concentrations of 12.5 to 25 µg/ml and cytotoxic effects against melanoma and ovarian cancer cell lines at the concentrations of 3 - 5 x 10−3 µg/ml; the structure of this compound was determined by spectroscopic methods. This compound portend a useful chemotherapeutic agent in the treatment of fungal and cancer infections Key words: Struchium sparganophora. Asteraceae, elemanolide lactone, vernodalinol.
Highlights
The search for natural occurring anti-infective agents for the treatment of fungal infections has led us to examine Struchium sparganophora, a culinary herb that has various medicinal uses among the traditional medicinal practitioners in western part of Nigeria.Fungal infections are traditionally divided into two distinct classes- superficial and systemic
Antimycotic agents are used for the treatment of fungal infections
S. sparganophora a culinary herb used for the treatment of gonorrhea (Aka and Ekekwe, 1995), measles and as an anti-poison agent (Burkil, 1995; Hutchison and Dalziel, 1963) has afforded elemanolide lactone, vernodalinol (Figure 1) apart from vernodalin and the 10 membered sesquiterpene lactone that was previously isolated from this plant (Kasim et al, 2011a; Jakupovic et al, 1987)
Summary
The search for natural occurring anti-infective agents for the treatment of fungal infections has led us to examine Struchium sparganophora, a culinary herb that has various medicinal uses among the traditional medicinal practitioners in western part of Nigeria. Antimycotic agents are used for the treatment of fungal infections. Of major importance later was the development of antimycotics of the azole-type, these. S. sparganophora a culinary herb used for the treatment of gonorrhea (Aka and Ekekwe, 1995), measles and as an anti-poison agent (Burkil, 1995; Hutchison and Dalziel, 1963) has afforded elemanolide lactone, vernodalinol (Figure 1) apart from vernodalin and the 10 membered sesquiterpene lactone that was previously isolated from this plant (Kasim et al, 2011a; Jakupovic et al, 1987). Table 1. 1H NMR spectra data of vernodalinol in pyridine
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