Abstract
INTRODUCTION: The prevalence of Non-alcoholic fatty liver disease (NAFLD) is increasing worldwide. This study aims to elucidate serum levels of Vitamin B12 in south Indian NAFLD patients. AIM: To investigate the correlation between Vitamin B 12 and NAFLD. MATERIALS AND METHODS: The study was designed as a case control study. Patients diagnosed to have NAFLD by standard clinical, radiological and biochemical investigations formed the study group. Healthy volunteers formed the control group. Fasting blood samples were collected at Star medical diagnostics and were subjected to biochemical analysis. Vitamin B12 was assayed using chemiluminiscence commercial kits. RESULTS: A total of 158 subjects were enrolled in the study. Cases constituted 79 and an equal number of controls were chosen by matching. Vitamin B 12 deficiency (<223 picograms/ml), was observed in 43% of NAFLD patients and none in the control group. CONCLUSION: Our results indicate that Vitamin B 12 deficiency may be one of the factors responsible for hepatic steatosis in NAFLD patients.
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