Abstract
erminalia ivoriensis A. Chev. (Combretaceae) is an Ivorian medicinal plant. There is little ethnobotanical and almost no chemical information available for this species. The aim of this study was to isolate phenolic compounds from T. ivoriensis. In this way, its ethyl acetate extract (Ea) was fractionated by silica gel column chromatography followed by Sephadex LH20 filtration. Elution solvents were methanol (MeOH), methylene chloride (Mc) and ethyl acetate (EtOAc). Analysis of the obtained fractions (F1-F4) by liquid chromatography coupled to positive electro-spray ionization tandem mass spectrometry (LC-ESI-MS/MS) afforded six known polyphenols: 1) 3,3'-di-O-methylellagic acid); 2) 3,7,8-tri-O-methylellagic acid; 3) Progallin A; 4) 3,3',4-O-Trimethyl-4'-O-β-D- glucopyranosylellagic acid; 5) Punicalagin and 6) Punicalin. All these natural products were isolated here for the first time from this plant. They presented various biological activities among which were anti-inflammatory, antioxidant and anti-HIV activities. Keywords: Terminalia, ivoriensis, LC-ESI-MS, isolation, characterization, polyphenols, activity, anti-inflammatory, antioxidant, anti-HIV.
Highlights
Terminalia ivoiriensis is a big tree belonging to the family Combretaceae
Analysis of the obtained fractions (F1-F4) by liquid chromatography coupled to positive electro-spray ionization tandem mass spectrometry (LC-ESI-MS/MS) afforded six known polyphenols: 1) 3,3'-di-O-methylellagic acid); 2) 3,7,8-tri-O-methylellagic acid; 3) Progallin A; 4) 3,3',4-O-Trimethyl-4'-O-β-Dglucopyranosylellagic acid; 5) Punicalagin and, 6) Punicalin
Concerning biological essay, its antioxidant and cytotoxic activities were reported by Ponou et al (2010), and its antifungal activities were evaluated by Ouattara et al (2013)
Summary
Terminalia ivoiriensis ( called Framire, Emery, Black afara and various other names) is a big tree belonging to the family Combretaceae. It is a large deciduous forest tree ranging in height from 15 to 46 m, branchless for up to 30 m, with diameter at breast height (dbh) of 2 to 4.75 m; bole clean, very straight with small buttresses and sometimes fluted. Its stem bark is used as antimalarial and tranquilizer agents (Lawal et al, 2010). This plant is used in Ivorian traditional medicine for numerous diseases like cough, diarrhea, hypertension, diabetes and tooth decay.
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