Abstract
In the present investigation, the hypolipidemic activity of different extracts of aerial parts of Chomelia asiatica (Linn) is shown. The evaluation dose of different extracts (petroleum ether, ethyl acetate and methanol) of C. asiatica was fixed at 200 mg/kg/day. Hypolipidemic activity was screened by inducing hyperlipidemia with the help of atherogenic diet (AD) in Wistar albino rats and plasma levels of different biochemical parameters such as total cholesterol, triglycerides, very low density lipoproteins (VLDL), low density lipoproteins (LDL), and high density lipoproteins (HDL) cholesterol, were determined. Thirty six male Wistar rats were divided into six groups, comprising six rats each. The rats in group 1 were treated with Standard chow diet, group 2 rats were treated atherogenic diet, group 3 rats were treated with AD + Pet.ether extracts of C. asiatica (200 mg/kg B.wt), group 4 rats were given AD + ethyl acetate extracts of C. asiatica (200 mg/kg B.wt), group 5 rats were given AD + methanol extracts of C. asiatica (200 mg/kg B.wt), group 6 AD + standard drug atorvastatin (1.2 mg/kg B.wt). At the end of 9 weeks, all rats were sacrificed by cervical dislocation after overnight fasting. The ethyl acetate extracts administrated rats were significantly (p<0.001) reduced in body weight, plasma and tissue total cholesterol, TG, phospholipids, plasma Low density lipoprotein and very low density lipoprotein; along with an increase in plasma high density lipoprotein when compared to that of AD treated groups of rats. Taking into account the outcomes, it can be concluded that the ethyl acetate extract of C. asiatica is a significant hypolipidemic agent, having preventive and curative activity against hyperlipidemia. Key words: Chomelia asiatica, atherogenic diet, rats, hypolipidemia.
Highlights
Coronary heart disease (CHD) is the main cause of death in Western countries and Asia
The treatment of ethyl acetate extracts of C. asiatica of rat fed with atherogenic diet (AD) significant (p
The ethyl acetate extracts of C. asiatica showed an improvement of the cardio vascular risk level by decrease of AI in the treated group by more than 61% (p < 0.01), as comparison to AD rats (Group II)
Summary
Coronary heart disease (CHD) is the main cause of death in Western countries and Asia. Among CHDs, ischemic heart disease (IHD) leads to increase in mortality rate. The number of heart patients suffering from IHD worldwide is gradually increasing. About 41% of the deaths in the United States are due to heart diseases.
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