English

Abstract

OBJECTIVE OF THE STUDY: To compare the effectiveness of two different doses of Dexmedetomidine, 0.6μg/kg body weight and 1μg/kg body weight in attenuating haemodynamic response to laryngoscopy and endotracheal intubation. MATERIAL AND METHODS: 90 ASA Class 1 patients posted for elective surgery divided into 3 groups, Group DX-0.6 receive Dexmedetomidine, 0.6μg/kg body weight Group DX-1 receive Dexmedetomidine, 1μg/kg body weight and Group CT receive normal saline. The HR, SBP, DBP, MAP recorded at different intervals. OBSERVATIONS: There was a decrease in mean HR in group DX-0.6 and group DX-1 (p=0.000) when compared to group CT at 1 st , 5 th and 10 th minutes after intubation and showed a fall in SBP in group DX-0.6 and group DX-1 at 2 nd min, 5 th min and 8 th min of drug administration and before and after induction compared to group CT. The decrease in mean SBP observed at 1st, 5th and 10th minutes after intubation in group DX-0.6 and group DX-1 was significant compared group CT (p=0.000). Significant fall in DBP in group DX-0.6 and group DX-1 at 8th min of drug administration and before and after induction compared to group CT. The decrease in mean DBP observed at 1 st , 5 th and 10 th minutes after intubation in group DX-0.6 and group DX-1 was significant compared to group CT (p=0.000). A fall in MAP in group DX-0.6 and group DX-1 at 2nd min, 5th min and 8th min of drug administration and before and after induction compared to group CT. The decrease in mean MAP observed at 1st, 5th and 10th minutes after intubation in group DX-0.6 and group DX-1 was significant compared to group CT(p=0.000). CONCLUSION: Dexmedetomidine - 0.6µg/kg body weight and 1µg/kg body weight are equally efficacious in obtunding the haemodynamic responses to laryngoscopy and endotracheal