Abstract
Objectives: The study was conducted to determine role of CVS in preventionof thalassemia and its sensitivity and specificity in those families with thalassemia positivehistory. Period: Three months. Study Design: Cross sectional study. Material and Methods:130 women who had thalassemic children and had come to transfusion centers for bloodtransfusion. Questionnaire was used for interview. Results: out of the total 130 women, 101were aware of CVS technique in which 50 had CVS. In 50 CVS, 15 had positive result while 35had negative result. In 15 positive cases 11 had abortion while four positive women refusedto abort. Out of the four women who completed their term, three were true positive while onecase was false positive. In 35 negative case results, 32 were true negative and three werefalse negative. Conclusion: Thalassemia is the commonest genetic disorder worldwide. It istransmitted from those parents who are carrier of thalassemia. Chorionic villous sampling playsimportant role in prevention of thalassemia during 1st trimester of pregnancy.
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