Abstract
The objective of the present study is to carry out bio-guided phytochemical investigation of Guiera senegalensis and Pseudocedrela kotschyi stem extracts. The two plants are used as toothpicks for oral hygiene. The inhibition test revealed a bacteriostatic effect of hexane extract PK1 of P. kotschyi against Streptococcus mutans ATCC 25175 and Streptococcus salivarius ATCC 20560, two bacterial cariogenic strains, with a decrease in the number of bacterial colonies of 1 Log/control. The aqueous extract GS5 obtained from the stems of G. senegalensis is bactericidal, with total inhibition of S. salivarius ATCC 20560. The antimicrobial effect of the stem extracts from the two plants studied varies according to the plant species and the type of bacterial strain. The phytocompounds 8-Hydroxy-6,7-dimethoxy-3-methylisochroman-4-one, 1-(4-hydroxy-3-methoxyphe-nyl) propane-1,2-dione and (4E, 15E) -Nonadeca-4,15- dien-10-one were isolated, respectively from GS5A extracts of G. senegalensis and PK1 of P. kotschyi by normal column chromatography. Key words: Guiera senegalensis, Pseudocedrela kotschyi, stem extracts, Streptococcus mutans, Streptococcus salivarius, spectroscopic characterization.  
Highlights
Plants have always been an indispensable source for human beings as regards health and food, especially in sub-Saharan Africa
G. senegalensis and P. kotschyi are often used in sub-Saharan regions to cure various diseases (Kerharo et al, 1948; Faye et al, 1980; Sanogo et al, 1998; Ancolio et al, 2002; Adamu et al, 2005; Alex et al, 2005; Hadissa and Deschamps, 2006; Ahua et al, 2007; Dieye et al, 2008; Somboro et al, 2011; Ohemu et al, 2014; Traore et al, 2014; Diarra et al, 2015; Sonibare et al, 2015; Kantati et al, 2016; Kpodar et al, 2016)
The objective of this study consists of a phytochemical investigation of G. senegalensis and P. kotschyi stem extracts by a bio-guided anti-cariogenic way to find out more new and effective antibacterials
Summary
Plants have always been an indispensable source for human beings as regards health and food, especially in sub-Saharan Africa. Plant stems are used in oral care. Such plant stems include Guiera senegalensis (Combretaceae) and Pseudocedrela kotschyi (Meliaceae), which are commonly used as toothbrush by the populations. The African continent is endowed with an impressive floristic biodiversity, with a large variety of plants for food and therapeutic needs. This natural floristic richness is only slightly valued chemically and pharmacologically. The bacterial resistance towards synthetic antibiotics is one of the major concerns of the medical research today (Ouelhadj et al, 2017). Medicinal plants are interesting alternatives to explore alongside synthetic drugs. The objective of this study consists of a phytochemical investigation of G. senegalensis and P. kotschyi stem extracts by a bio-guided anti-cariogenic way to find out more new and effective antibacterials
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