Abstract
This chapter discusses some of the opportunities for applying engineering principles and practices to the development of a new class of drug dosage forms, called therapeutic systems. These have the aim of improving, and eventually optimizing, the therapeutic potential of drugs. The full therapeutic potential of many drugs fails to be realized because of the limitations of conventional dosage forms. The chapter describes a strategy of innovation through engineering development of controlled delivery systems for drugs. It is a new strategy in an industry that has innovated through synthesis of new chemical compounds and screening for their pharmacological activity, with limited development of dosage forms. The chapter focuses on the temporal and spatial aspects of therapeutics. When these are jointly considered with the aim of achieving the full therapeutic potential of a particular drug, the design theme becomes the optimization of patterns and portals of drug administration.
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