Abstract

The generation of genomic data from mammoths and Neanderthals has reinvigorated discussion about whether extinct species could be brought back within the foreseeable future. However, post-mortem DNA decay rapidly reduces the number and quality of surviving DNA fragments, consequently increasing rates of sequencing error and forming a significant obstacle to accurate sequence reconstruction. Recent work has shown that it is possible to engineer a polymerase capable of using even highly damaged fragments as template sequences.

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Topics from this Paper

  • Generation Of Genomic Data
  • Template Sequences
  • Extinct Species
  • Generation Of Data
  • Accurate Reconstruction
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