Engineered Celery-Structured Electrospun Fibers Surface and Its Initial Cell Attachment Ability Effect.

Abstract

The fabrication of various types of scaffolds using electrospinning has been greatly researched for tissue engineering applications in recent times. The rapid initial cell adhesion in electrospun scaffolds helps in the rapid recovery of graft sites. The characteristics of nanofibrous scaffolds can be improved by modifying the topological features and surface of the nanofibers. Previous studies have shown that the scaffold structure is related to a cell attachment ability. In this study, we modified the surface of the fibers to mimic celery structure. It was confirmed that solvent evaporation and polymer concentration influenced the formation of the surface. This structural property can improve the initial adhesion ability of cells. Cellulose acetate solutions were prepared and tested in various concentrations (15 wt%, 20 wt%, and 30 wt%). Scanning electron microscopy (SEM), tensile test and cell experiments were performed to evaluate the physical properties and biocompatibility. The structure of the present nanofiber can be applied as a very effective scaffold and it is expected to have a positive effect in the tissue engineering field.