Endotoxinemia and Intensity of Humoral Immunity in Surgical Treatment of Acute Diseases of Extrahepatic Biliferous Tracts

Abstract

The level of systemic endotoxinemia and intensity of antiendotoxine humoral immunity in surgical treatment of acute diseases of extrahepatic biliary tracts are studied. Two groups of patients were examined. The patients with acute cholecystitis complicated by mechanical jaundice were in the first group, the patients with various forms of acute cholecystitis without disorders of bile outflow were in the second group. It is established that the high level of systemic endotoxinemia is found in patients with signs of mechanical jaundice in preoperative period, in this case the level of general blood bilirubine is directly correlated with the level of systemic endotoxinemia in both groups of patients. The decrease of humoral antiendotoxine immunity in preoperative period and its recovery in postoperative period are noted in patients with mechanical jaudice phenomena as the level of systemic endotoxinemia decreases and bile passage into intestine is recovered.