Abstract
The formation of the vertebrate vasculature involves the acquisition of endothelial cell identities, sprouting, migration, remodeling and maturation of functional vessel networks. To understand the cellular and molecular processes that drive vascular development, live-imaging of dynamic cellular events in the zebrafish embryo have proven highly informative. This review focusses on recent advances, new tools and new insights from imaging studies in vascular cell biology using zebrafish as a model system.
Highlights
Vascular development is an early and essential process in the formation of a viable vertebrate embryo
We investigate recent studies that have used dynamic imaging and in vivo cell biology to understand endothelial cells (ECs) development in zebrafish
We highlight key Zebrafish Endothelial Cell Dynamic technical achievements and new biology uncovered, we will give a broad overview of the current toolbox available and we briefly describe potential new future directions
Summary
Vascular development is an early and essential process in the formation of a viable vertebrate embryo. In addition to genetic analyses, recent studies have used dynamic imaging of cell behavior as angioblasts migrate to the midline to give rise to the dorsal aorta (DA) and the posterior cardinal vein (PCV).
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