Endoscopic Trimodal Imaging Improves the Detection of High-Grade Dysplasia (HGD) and Early Cancer (EC) in Barrett’s Esophagus: An International Multicenter Study

Abstract

Background: Standard endoscopy and random biopsy have a poor sensitivity for detection of dysplasia in Barrett’s esophagus (BE). In a single-center study, autofluorescence imaging (AFI) has been shown to increase this sensitivity at the expense of a relatively high false-positive rate. This false-positive rate may be reduced by the use of narrow band imaging (NBI) for detailed inspection of AFI-suspicious lesions, but this requires a separate endoscopy system. In this international multicenter study, we prospectively evaluated Endoscopic Tri-Modal Imaging (ETMI), a new endoscopy system that incorporates high-resolution endoscopy (HRE), AFI, and NBI in a single device with magnification in the HRE and NBI mode.