Abstract
ABSTRACT Prolonged supplementation with adequate or even high amounts of dietary iodine of 317 goitrous and 200 nongoitrous individuals from the endemic area of the Cauca Valley resulted in thyroidal 131I uptakes within the low normal range of values reported from nonendemic areas; serum PBI concentrations were similar to those accepted as normal; and urinary iodine excretions were above the levels observed in non-endemic areas. Normal renal clearances of iodine and high plasma inorganic iodide (PII) have also been found. The increments in thyroidal 131I uptakes and PB127I concentrations after the administration of thyrotropin, normal values for PB131I and normal conversion ratios indicate that goitrous glands from the Cauca Valley are normally sensitive to tropic hormone, are not under maximal endogenous TSH stimulation, and therefore have an adequate functional reserve. Thus, it appears that intrathyroidal factors and not TSH activity account for the retardation in hormonal synthesis that has been encou...
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