British Journal of Anaesthesia | VOL. 73

End-tidal partial pressure of carbon dioxide does not accurately reflect P a co2 in rabbits treated with acetazolamide during anaesthesia

Publication Date Aug 1, 1994


Acetazolamide, a carbonic anhydrase inhibitor, may cause significant disturbances in carbon dioxide transport and elimination. In this study, end-tidal carbon dioxide monitoring has been used to study the correlation between arterial carbon dioxide (PaCO2) and end-tidal carbon dioxide partial pressure (PE'CO2) in rabbits treated with acetazolamide. A significant difference in (PaCO2-PE'CO2) developed immediately after administration of acetazolamide and persisted for more than 2 h. It is concluded that PE'CO2 did not reflect accurately PaCO2 and the ventilatory status of the rabbit which received acetazolamide within 2 h.

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End-tidal Carbon Dioxide Partial Pressure
Arterial Carbon Dioxide Partial Pressure
End-tidal Carbon Dioxide Monitoring
Carbon Dioxide Partial Pressure
End-tidal Partial Pressure
Administration Of Acetazolamide
Carbon Dioxide Transport
Carbon Dioxide
End-tidal Carbon Dioxide
Arterial Carbon Dioxide

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