Colloids and Surfaces B: Biointerfaces | VOL. 75
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Encapsulation of proteins in poly(l-lactide-co-caprolactone) fibers by emulsion electrospinning

Publication Date Feb 1, 2010

Abstract

This study was aimed at investigating emulsion electrospinning to prepare biodegradable fibrous mats with encapsulation of human-nerve growth factor (NGF). One of the best methods for fabricating a bio-functional tissue engineering scaffold is to load bioactive agent into the scaffold. In this work, the feasibility of incorporating NGF into poly(L-lactide-co-caprolactone) fibers by emulsion electrospinning has been studied. The release behavior of encapsulated bovine serum albumin (BSA) was investigated. The bioactivity of NGF released from fibrous mats was verified by testing the neurite outgrowth of rat pheochromocytoma cells (PC12). Furthermore, the process of fiber forming during emulsion electrospinning was discussed. The results demonstrate that emulsion electrospun fibers can successfully encapsulate proteins and release them in a sustained manner. The bioactivity of NGF released from emulsion electrospun fibers was confirmed by PC12 bioassays.

Concepts
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Emulsion Electrospinning
Encapsulation Of Proteins
Fibrous Mats
Bovine Serum Albumin
Neurite Outgrowth Of Cells
Bio-functional Scaffold
Sustained Manner
Outgrowth Of Cells
Human-nerve Growth Factor
Emulsion Electrospun

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