Abstract
A model system representing a protected form of the four central rings of the antitumor compound lomaiviticin A has been synthesized (outlined in red in the picture). The approach features an intramolecular furan Diels–Alder reaction, a stereoselective oxidative enolate coupling to dimerize the “halves,” and a base-initiated cascade reaction. The 1,4-diketone of the central ring system exists as a stable cyclic hydrate. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704830_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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