Abstract
The enantioselective aldol reaction is among the most useful and well-developed transformations for the synthesis of chiral materials. Despite this, gaps in asymmetric aldol methodology still exist. The authors present the first example of a general, highly enantioselective Mukaiyama aldol reaction between aryl ketones and glyoxylates. An indium-PyBox complex is used as a chiral Lewis acid to induce asymmetry.
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