Abstract
An enantioselective Henry reaction was efficiently carried out under mild reaction conditions in the presence of catalytic 9- epi and natural Cinchona alkaloids and copper (II) acetate. The best catalytic performance was observed for native quinine (12 mol %) and Cu(OAc) 2 (10 mol %). Aromatic and aliphatic aldehydes with nitromethane and its α-substituted derivatives provided the corresponding β-nitroalcohols in good to reasonable yields, high syn-diastereoselectivity, and ( S)-enantioselectivity of up to 94% ee.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
