Abstract
Under the ‘double-catalytic condition’ protocol using the (R,R)-DBFOX/Ph complex of nickel(II) perchlorate hexahydrate and tetramethyl-piperidine, enol lactones were formed with high enantioselectivity. The mechanism proceeds via an enantioselective Michael addition followed by enolization of the diketone moiety, then cyclization with concomitant displacement of the pyrazole auxiliary. Catalyst loadings can be reduced to 2 mol% and use of β-hydroxy-lactones instead of the diketone is also reported.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
