Enantioselective Direct Bisvinylogous 1,6‐Additions of β‐Allyl‐2‐cyclohexenone to α,α‐Dicyanodienes through Trienamine Catalysis

Abstract

AbstractAn asymmetric direct ϵ‐regioselective bisvinylogous 1,6‐addition reaction of β‐allyl‐2‐cyclohexenone to β‐substituted α,α‐dicyanodienes was developed through trienamine catalysis of a bifunctional primary amine–thiourea compound. Excellent enantioselectivity (up to 97 % ee) was obtained even through such a remote reaction mode. In addition, more complex cyclic frameworks could be efficiently constructed with high stereoselectivity.