Abstract
A screening with 15 strains of bacteria and fungi targeted at the production of specific hydroxylated benzylic derivatives of indan 1 and tetralin 2 was carried out. Mortierella isabellina, Mortierella ramanniana and Beauveria bassiana were shown to mediate the respective conversions to 1-indanol ( 3) and 1-tetralol ( 4), the most satisfactory results being obtained with M. isabellina, which gave 78% conversion of 1 to (1 R)- 3 (64% yield, 86% ee) after a 2-day-incubation, and 52% conversion of 2 to (1 R)- 4 (38% yield, 92% ee) in a 4-day-incubation. Over-oxidation of alcohols 3 and 4 during the reactions resulted on the formation of 1-indanone and 2-tetralone, respectively.
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