Abstract
AbstractThe retentions and enantiomeric resolutions of remoxipride, propranolol, and trimipramine were studied using a CHIRAL‐AGP column with micellar mobile phases and aliphatic, anionic additives. The retentions of the compounds, which in neat buffer solution were very high (k′ > 50), could be decreased to k′ < 10 by adding a mixture of Tween® 20 and heptanoic acid to the mobile phase. The presence of the aliphatic acid was essential in order to increase the enantiomeric selectivity. An efficiency enhancement was obtained by increasing the temperature. With a mobile phase composition optimized for the separation of remoxipride, the possibility of detecting levels of the enantiomeric impurity (R‐remoxipride) down to 0.025% in the drug was demonstrated. © 1993 Wiley‐Liss, Inc.
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