Abstract
The optical isomers of amphetamine and methamphetamine in the human urine were clearly separated by direct HPLC analysis using a chiral stationary phase. This direct HPLC was applied to the enantiomeric resolution of amphetamines in the methamphetamine abusers' urine and in the Parkinsonian urine after (R)-(-)-deprenyl administration. (S)-(+)-Amphetamine and (S)-(+)-methamphetamine were only detected in the urine from several methamphetamine abusers. On the contrary, (R)-(-)-amphetamine and (R)-(-)-methamphetamine were only detected as metabolites in the Parkinsonian urine treated with (-)-deprenyl. Enantiomer analysis may provide valuable information about the original substrate in the metabolic pathway. This simple and convenient method is suitable for the enantiomeric analysis for forensic purposes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
