Abstract
AbstractThe synthesis of chiral γ‐keto bisphosphonates is described. Michael addition of cyclic ketones to vinyl gem‐bisphosphonate catalyzed by 0.1 mol equiv. (S)‐(+)‐1‐(2‐pyrrolidinyl)pyrrolidine and benzoic acid gave the products in yields of up to 86 %, dr (cis/trans) > 1:99 and ee of up to 99 %. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
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