Abstract
AC Biosusceptometry (ACB) was previously employed towards recording gastrointestinal motility. Our data show a reliable and successful evaluation of gastrointestinal transit of liquid and solid meals in rats, considering the methods scarcity and number of experiments needed to endorsement of drugs and medicinal plants. ACB permits real time and simultaneous experiments using the same animal, preserving the physiological conditions employing both meals with simplicity and accuracy.
Highlights
Gastrointestinal (GI) motor activity consist of an intricate group of functions that are essential for life [1], and disorders of GI transit and/or contractility are common [2]
Technique A single AC Biosusceptometry (ACB) sensor works as a double magnetic flux transformer without any nucleus and has two coaxial pairs of coils separated by a baseline of 15 cm [13,17]
The excitation coil works with a frequency of 10 kHz generated by lock-in amplifiers and a current of 88 mA that produces a magnetic field of 20 G and induces equal magnetic flux in the detection coils
Summary
Gastrointestinal (GI) motor activity consist of an intricate group of functions that are essential for life [1], and disorders of GI transit and/or contractility are common [2]. GI transit can be quantified in rats, by measuring the movement of charcoal, dye, radiopaque markers or other non-absorbable materials [5,6]. This procedure requires the sacrifice of a large number of animals in order to determine the propulsion of such markers within the gut at predetermined time intervals and usually measurements of gastric emptying and small bowel transit involves separate groups of animals [5]
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