Abstract
The study regarding load-independent effects of empagliflozin contribute to improved cardiac function in experimental heart failure with reduced ejection fraction is very interesting. But there are a few things we need to pay attention to.
Highlights
The study regarding load-independent effects of empagliflozin contribute to improved cardiac function in experi‐ mental heart failure with reduced ejection fraction is very interesting
The present Commentary refers to the recently published article by Connelly et al [1] describing that empagliflozin contributes to improving cardiac function in experimental heart failure with reduced ejection fraction (HFrEF)
EMPA-REG OUTCOME demonstrated that patients with type 2 diabetes at high risk for cardiovascular events who received empagliflozin, as compared with placebo, had a lower rate of the primary composite cardiovascular outcome and of death from any cause when the study drug was added to standard care [2]
Summary
The study regarding load-independent effects of empagliflozin contribute to improved cardiac function in experi‐ mental heart failure with reduced ejection fraction is very interesting. The present Commentary refers to the recently published article by Connelly et al [1] describing that empagliflozin contributes to improving cardiac function in experimental heart failure with reduced ejection fraction (HFrEF). It has been shown that empagliflozin improves hemodynamics in a hypertensive heart failure rat model, associated with renal protection, attenuated cardiac fibrosis, and normalization of HF genes [3].
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