Abstract
To generate hypotheses on possible sources of Shiga toxin-producing Escherichia coli (STEC) serogroup O80 associated hemolytic-uremic syndrome (HUS), we explored differences in factors associated with STEC O80 associated HUS, compared with STEC O157 or STEC of other serogroups, in France during 2013–16. STEC was isolated from 153/521 (30%) reported HUS cases: 45 serogroup O80, 46 O157 and 62 other serogroups. Median ages were 1.1 years, 4.0 years and 1.8 years, respectively. O80 infected patients were less likely to report ground beef consumption (aOR [adjusted Odds Ratio] 0.14 95% CI [Confidence Interval] 0.02–0.80) or previous contact with a person with diarrhea or HUS (aOR 0.13 95%CI 0.02–0.78) than patients infected with STEC O157. They were also less likely to report previous contact with a person presenting with diarrhea/HUS than patients infected with other serogroups (aOR 0.13 95%CI 0.02–0.78). STEC O80 spread all over France among young children less exposed to known risk factors of O157 or other STEC infections, suggesting the existence of different reservoirs and transmission patterns.
Highlights
Shiga-toxin-producing Escherichia coli (STEC) infections can result in gastroenteritis, enterocolitis, and bloody diarrhea [1]
153 hemolytic-uremic syndrome (HUS) cases with STEC infection were included in the study: with STEC O80, with STEC O157 and 62 with STEC of any other serogroup
Food questionnaires were completed for 34 STEC O80, 42 STEC O157, and 52 STEC of other serogroups
Summary
Shiga-toxin-producing Escherichia coli (STEC) infections can result in gastroenteritis, enterocolitis, and bloody diarrhea [1]. In up to 10% of STEC infections hemolytic-uremic syndrome (HUS) may develop, making STEC the main cause of acute renal failure in children [1]. Humans can contract STEC infection through consumption of food items contaminated by the animal reservoir such as undercooked beef, raw milk, or raw vegetables, through contact with animals or an environment contaminated by colonized animals, or through person-toperson contact in particular in nurseries or within families [1,2,3,4,5,6].
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